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Load containing implants should not be released until:

  1. The sterilization process time has been reduced

  2. The BI PCD has expired

  3. The BI result is known to be negative

  4. Only external indicators show positive change

The correct answer is: The BI result is known to be negative

Load containing implants should not be released until the Biological Indicator (BI) result is known to be negative. Implants are critical items, and ensuring that the BI result is negative confirms that the sterilization process has effectively destroyed any potential microorganisms that could lead to contamination. Waiting for the BI result provides the highest level of assurance that the items, especially implants, are safe for use on patients. Options A, B, and D are incorrect because: A. The sterilization process time should not be reduced as it may compromise the effectiveness of sterilization. B. Waiting for the expiration of the Biological Indicator PCD alone is not sufficient to ensure the sterility of the load. D. Relying only on external indicators showing a positive change may not provide accurate information about the sterility inside the pack.